Introduction
DIAMOND is a sequence aligner for protein and translated DNA searches,
designed for high performance analysis of big sequence data. The key
features are:
- Pairwise alignment of proteins and translated DNA at 100x-10,000x
speed of BLAST.
- Clustering protein sequences with high sensitivity and scalability
including linear-time scaling and parallelization across many
compute nodes.
- Frameshift alignments for long read analysis.
- Low resource requirements and suitable for running on standard
desktops or laptops.
- Various output formats, including BLAST pairwise, tabular and XML,
as well as taxonomic classification.
Documentation
The online documentation is located at the GitHub Wiki.
Support
DIAMOND is actively supported and developed software. Please use the issue tracker for malfunctions and the GitHub discussions for questions, comments, feature requests, etc. I also provide live support on Discord. Don’t be too shy to ask!
Contributing
See Contributing.
About
DIAMOND is developed by Dr. Benjamin J. Buchfink, independent scientist, Tübingen, Germany,
supported by the Max Planck Society for the Advancement of Science. From 2019-2024,
it was developed by Benjamin J. Buchfink at the Drost lab, Max Planck Institute for Biology Tübingen.
From 2018-2019, its development was supported by the German Federal Ministry
for Economic Affairs and Energy through an EXIST grant. From 2016-2018, it was developed
by Benjamin J. Buchfink as an independent researcher. From 2013-2015, the initial version
was developed by Benjamin J. Buchfink at the Huson lab, University of Tübingen, Germany.
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Publications:
-
Buchfink BJ, Barbé É, Ashkenazy H, Reuter K, Kennedy JA, Drost HG, "Clustering the protein
universe of life using DIAMOND DeepClust", Nature Methods 23, 724-727 (2026).
doi:10.1038/s41592-026-03030-z
-
Buchfink BJ, Reuter K, Drost HG, "Sensitive protein alignments at tree-of-life
scale using DIAMOND", Nature Methods 18, 366–368 (2021).
doi:10.1038/s41592-021-01101-x
Original publication to cite DIAMOND until v0.9.25:
- Buchfink BJ, Xie C, Huson DH, "Fast and sensitive protein alignment
using DIAMOND", Nature Methods 12, 59-60 (2015).
doi:10.1038/nmeth.3176
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